The Relationship between Allostasis and Mental Health Patterns in a Pre-Deployment French Military Cohort
Open Access
- 12 October 2021
- journal article
- research article
- Published by MDPI AG in European Journal of Investigation in Health, Psychology and Education
- Vol. 11 (4), 1239-1253
- https://doi.org/10.3390/ejihpe11040090
Abstract
(1) Background: While a number of studies among military personnel focus on specific pathologies such as post-traumatic stress disorder (PTSD), anxiety, and depression, they do not address the cumulative impact on mental health of stressors related to the profession. The present study aims to determine the relationship between allostatic load and mental health status in a cohort of fit-for-duty soldiers prior to their deployment to Afghanistan. The aim is to better-define the consequences of stressor adjustment. (2) Methods: A cohort of 290 soldiers was evaluated in a cross-sectional study with respect to psychopathology (PTSD, anxiety, depression), psychological functioning (stress reactivity, psychological suffering), and allostatic profile (urinary cortisol and 8-iso-PGF2α, blood cortisol and BDNF). A hierarchical cluster analysis was used to identify allostatic patterns. (3) Results: Around 10% of the cohort reported high scores for psychopathology, and biological alterations were identified. For the remainder, four allostatic profiles could be identified by their psychological functioning. (4) Conclusions: Both biological and psychological assessments are needed to characterize subthreshold symptomatology among military personnel. The psychological significance of allostatic load should be considered as a way to improve health outcomes.Keywords
This publication has 82 references indexed in Scilit:
- Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484)Molecular Psychiatry, 2013
- Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: A systematic review and meta-analysisClinical Psychology Review, 2012
- Neuroticism, Depressive Symptoms, and Serum BDNFPsychosomatic Medicine, 2011
- Diagnostic and Statistical Manual of Mental DisordersPsychiatry Research, 2011
- Stress risk factors and stress-related pathology: Neuroplasticity, epigenetics and endophenotypesStress, 2011
- Serum BDNF levels before treatment predict SSRI response in depressionProgress in Neuro-Psychopharmacology and Biological Psychiatry, 2011
- The Hospital Anxiety and Depression Scale: A diagnostic meta-analysis of case-finding abilityJournal of Psychosomatic Research, 2010
- New onset and persistent symptoms of post-traumatic stress disorder self reported after deployment and combat exposures: prospective population based US military cohort studyBMJ, 2008
- Protection and Damage from Acute and Chronic Stress: Allostasis and Allostatic Overload and Relevance to the Pathophysiology of Psychiatric DisordersAnnals of the New York Academy of Sciences, 2004
- The Hospital Anxiety and Depression ScaleActa Psychiatrica Scandinavica, 1983