Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1H-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate
Open Access
- 1 January 2014
- journal article
- Published by Scientific Research Publishing, Inc. in Journal of Crystallization Process and Technology
- Vol. 04 (03), 140-144
- https://doi.org/10.4236/jcpt.2014.43018
Abstract
An important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl diacetate was synthesized by directly coupling the bromotriazole with the protected ribose sugar, and have given the corresponding product in moderate yield. Its structure and conformation were confirmed by single crystal X-ray diffraction.Keywords
This publication has 1 reference indexed in Scilit:
- C-S Coupling Using a Mixed‐Ligand Pd Catalyst: A Highly Effective Strategy for Synthesizing Arylthio‐Substituted HeterocyclesChemistry – A European Journal, 2013