Periosteum mechanobiology and mechanistic insights for regenerative medicine
- 30 November 2016
- journal article
- review article
- Published by Portico in BoneKEy Reports
- Vol. 5, 857
- https://doi.org/10.1038/bonekey.2016.70
Abstract
Periosteum is a smart mechanobiological material that serves as a habitat and delivery vehicle for stem cells as well as biological factors that modulate tissue genesis and healing. Periosteum's remarkable regenerative capacity has been harnessed clinically for over two hundred years. Scientific studies over the past decade have begun to decipher the mechanobiology of periosteum, which has a significant role in its regenerative capacity. This integrative review outlines recent mechanobiological insights that are key to modulating and translating periosteum and its resident stem cells in a regenerative medicine context.Keywords
This publication has 60 references indexed in Scilit:
- Periosteum, bone's “smart” bounding membrane, exhibits direction-dependent permeabilityJournal of Bone and Mineral Research, 2012
- Concise Review: The Periosteum: Tapping into a Reservoir of Clinically Useful Progenitor CellsStem Cells Translational Medicine, 2012
- The skeletal muscle secretome: an emerging player in muscle–bone crosstalkBoneKEy Reports, 2012
- Surgical Membranes as Directional Delivery Devices to Generate Tissue: Testing in an Ovine Critical Sized Defect ModelPLOS ONE, 2011
- Net Change in Periosteal Strain During Stance Shift Loading After Surgery Correlates to Rapid De Novo Bone Generation in Critically Sized DefectsAnnals of Biomedical Engineering, 2011
- Effects of mechanical loading patterns, bone graft, and proximity to periosteum on bone defect healingJournal of Biomechanics, 2010
- Structural and cellular features in metaphyseal and diaphyseal periosteum of osteoporotic ratsJournal of Molecular Histology, 2010
- Skeletal Cell Fate Decisions Within Periosteum and Bone Marrow During Bone RegenerationJournal of Bone and Mineral Research, 2009
- Modulation of Stem Cell Shape and Fate A: The Role of Density and Seeding Protocol on Nucleus Shape and Gene ExpressionTissue Engineering, Part A, 2008
- Immediate Microcirculatory Derangements in Skeletal Muscle and Periosteum after Closed Tibial FractureThe Journal of Trauma and Acute Care Surgery, 2003