Creativity, innovation, creation and entrepreneurship have become the core driving force of China's economic development and urban transformation in the new era. To promote the sustainable development of the Yangtze River Delta with higher quality, it is necessary to build a community of regional interests, give play to the advantages of regional industries, and form a world-class city cluster with global competitiveness on the basis of grasping the mission, target positioning and strategic path of the Time, with reliance on the region and the whole country, looking around the world and facing the future. This paper analyzed the creative industry development in the 25 major cities of the Yangtze river delta through three indicators, including the international market share index (IMS), trade competitiveness index (TC) and revealed comparative advantage index (RCA). From the two perspectives of creative goods and services, it compared the international competitiveness of creative industry between China and some major countries in the world. Finally, in the background of the digital era, countermeasures were proposed from the perspectives of cross-border integration and symbiotic development of digital economy, digital technology and creative industry, the spatial collaboration and symbiotic development of creative industry of the city cluster in Yangtze River Delta, talent training and intellectual property protection.