Autophagosome biogenesis and human health
Open Access
- 2 June 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell Discovery
- Vol. 6 (1), 1-14
- https://doi.org/10.1038/s41421-020-0166-y
Abstract
Autophagy degrades the cytoplasmic contents engulfed by autophagosomes. Besides providing energy and building blocks during starvation via random degradation, autophagy selectively targets cytotoxic components to prevent a wide range of diseases. This preventive activity of autophagy is supported by many studies using animal models and reports identifying several mutations in autophagy-related genes that are associated with human genetic disorders, which have been published in the past decade. Here, we summarize the molecular mechanisms of autophagosome biogenesis involving the proteins responsible for these genetic disorders, demonstrating a role for autophagy in human health. These findings will help elucidate the underlying mechanisms of autophagy-related diseases and develop future medications.Keywords
Funding Information
- MEXT | JST | Core Research for Evolutional Science and Technology (JPMJCR17H6)
- Human Frontier Science Program
- MEXT | Japan Society for the Promotion of Science (19H03454)
- Takeda Science Foundation
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