Research Progress of Cellular Immunity and Type 1 Diabetes Mellitus
- 1 January 2020
- journal article
- Published by Hans Publishers in Hans Journal of Biomedicine
- Vol. 10 (02), 9-12
- https://doi.org/10.12677/hjbm.2020.102002
Abstract
1型糖尿病(Type 1 diabetes mellitus, T1DM)是一种具有致病性、适应性和自身免疫性的复杂疾病,可导致β细胞的破坏和功能障碍。目前,普遍认为T细胞是大多数T1DM患者β细胞损伤的关键介质,此外,B细胞、巨噬细胞及树突状细胞等也在其发病过程中发挥着不容忽视的作用。 Type 1 diabetes mellitus (T1DM) is a complex disease that is pathogenic, adaptive, and autoim-mune, which can cause β-cell destruction and dysfunction. At present, T cells are generally con-sidered to be the key mediator of β cell damage in most T1DM patients. In addition, B cells, mac-rophages, and dendritic cells also play a role that cannot be ignored.This publication has 11 references indexed in Scilit:
- Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarizationCell Death & Disease, 2019
- B lymphocytes expressing high levels of PD-L1 are key regulators of diabetes development in non-obese diabetic miceMolecular Immunology, 2019
- ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunityJCI Insight, 2017
- Advances in the cellular immunological pathogenesis of type 1 diabetesJournal of Cellular and Molecular Medicine, 2014
- Type 1 diabetesThe Lancet, 2013
- Type 1 Diabetes: Etiology, Immunology, and Therapeutic StrategiesPhysiological Reviews, 2011
- Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetesDiabetes & Metabolism, 2009
- Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in miceJCI Insight, 2007
- The Cross-Regulatory Relationship Between Human Dendritic and Regulatory T Cells and its Role in Type 1 Diabetes MellitusThe Review of Diabetic Studies, 2007
- Lipopolysaccharide-Activated B Cells Down-Regulate Th1 Immunity and Prevent Autoimmune Diabetes in Nonobese Diabetic MiceThe Journal of Immunology, 2001