Development and evaluation of taste masked dry syrup formulation of potassium chloride
Open Access
- 22 January 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in AAPS Open
- Vol. 5 (1), 1
- https://doi.org/10.1186/s41120-019-0030-z
Abstract
Potassium chloride (KCl) syrup is widely used for the oral treatment of the hypokalemia. However, it is associated with unacceptable taste. In the present study, we sought to develop a palatable and easy to reconstitute KCl dry syrup as a commercially viable alternative to currently available KCl syrup. We explored the potential of Eudragit E100 as a taste-masking polymer to coat and improve the palatability of the KCl. With the help of fluid bed processor, KCl was coated with the solution containing varying amounts of Eudragit E100 (4, 6, 10 and 15%). Coating with 10% polymer solution enabled optimal fluid bed processing, higher entrapment of the KCl (81%) and better in vitro release profile in 0.1 N HCl and pH 6.8 phosphate buffer. A dry syrup formulation containing Eudragit E100 coated KCl with good physical and chemical stability in dry and reconstituted state was developed. The palatability of the optimized formulation and commercially available KCl syrup was evaluated using the Electronic Taste Sensing Machine. The developed formulation showed~ 2-fold better taste-masking compared to the commercial KCl syrup. Thus, present investigation describes the development of an effective alternative to the current KCl syrup that can offer better palatability, stability and patient compliance.Keywords
This publication has 29 references indexed in Scilit:
- Taste Masked Microspheres of Ofloxacin: Formulation and Evaluation of Orodispersible TabletsScientia Pharmaceutica, 2011
- Development and Evaluation of Cetirizine HCl Taste-Masked Oral Disintegrating TabletsAAPS PharmSciTech, 2010
- An Electronic Tongue: Evaluation of the Masking Efficacy of Sweetening and/or Flavoring Agents on the Bitter Taste of EpinephrineAAPS PharmSciTech, 2010
- Evaluation of a taste sensor instrument (electronic tongue) for use in formulation developmentInternational Journal of Pharmaceutics, 2009
- Design and Optimization of Mefloquine Hydrochloride Microparticles for Bitter Taste MaskingAAPS PharmSciTech, 2008
- Formulation and Evaluation of Fast Dissolving Films for Delivery of Triclosan to the Oral CavityAAPS PharmSciTech, 2008
- Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid-disintegrating tabletsAAPS PharmSciTech, 2007
- The effect of various polymeric coating systems on the dissolution and tableting properties of potassium chloride microcapsulesInternational Journal of Pharmaceutics, 1991
- What Happens to Tablets and Capsules in the Stomach: Endoscopic Comparison of Disintegration and Dispersion Characteristics of Two Microencapsulated Potassium FormulationsJournal of Pharmaceutical Sciences, 1990
- UPPER GASTROINTESTINAL LESIONS AFTER POTASSIUM CHLORIDE SUPPLEMENTS: A CONTROLLED CLINICAL TRIALThe Lancet, 1982