Challenges in ensuring the generalizability of image quantitation methods for MRI
- 29 September 2021
- journal article
- research article
- Published by Wiley in Medical Physics
- Vol. 49 (4), 2820-2835
- https://doi.org/10.1002/mp.15195
Abstract
Image quantitation methods including quantitative MRI, multiparametric MRI, and radiomics, offer great promise for clinical use. However, many of these methods have limited clinical adoption, in part due to issues of generalizability, i.e., the ability to translate methods and models across institutions. Researchers can assess generalizability through measurement of repeatability and reproducibility, thus quantifying different aspects of measurement variance. In this article, we review the challenges to ensuring repeatability and reproducibility of image quantitation methods as well as present strategies to minimize their variance to enable wider clinical implementation. We present possible solutions for achieving clinically acceptable performance of image quantitation methods and briefly discuss the impact of minimizing variance and achieving generalizability towards clinical implementation and adoption. This article is protected by copyright. All rights reservedKeywords
Funding Information
- National Institutes of Health (R01 AR077604, R01 EB002524, K24 AR062068, P41 EB015891)
This publication has 145 references indexed in Scilit:
- Quantitative multi-parameter mapping of R1, PD*, MT, and R2* at 3T: a multi-center validationFrontiers in Neuroscience, 2013
- Metastatic Ovarian and Primary Peritoneal Cancer: Assessing Chemotherapy Response with Diffusion-weighted MR Imaging—Value of Histogram Analysis of Apparent Diffusion CoefficientsRadiology, 2011
- Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopyJournal of Magnetic Resonance Imaging, 2011
- Repeatability of magnetic resonance elastography for quantification of hepatic stiffnessJournal of Magnetic Resonance Imaging, 2010
- New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)European Journal of Cancer, 2009
- Intensity non-uniformity correction using N3 on 3-T scanners with multichannel phased array coilsNeuroImage, 2008
- Report on a multicenter fMRI quality assurance protocolJournal of Magnetic Resonance Imaging, 2006
- A standardised method for measuring magnetisation transfer ratio on MR imagers from different manufacturers—the EuroMT sequenceMagnetic Resonance Materials in Physics, Biology and Medicine, 2005
- Modified Look‐Locker inversion recovery (MOLLI) for high‐resolution T1 mapping of the heartMagnetic Resonance in Medicine, 2004
- Rapid combined T1 and T2 mapping using gradient recalled acquisition in the steady stateMagnetic Resonance in Medicine, 2003