The Efficacy of Combination Regime in Helicobacter Pylori Eradication: A Cross-Sectional Study from an Experienced Endoscopy Center

Abstract

Aim: The success of antibiotics used for eradication in the treatment of Helicobacter pylori (Hp)-positive gastritis is controversial. This study aims to evaluate the post-treatment eradication success/failure of Hp-positive gastritis cases, discuss antibiotic resistance, and what we can do additionally. Methods: The data of 1,471 patients who underwent upper gastrointestinal endoscopy between January 1 and December 31, 2019, were retrospectively evaluated through the hospital digital recording system. Of these, data of 126 patients who have been diagnosed with HP-positive gastritis and treated with a trio of clarithromycin, amoxicillin, and omeprazole were analyzed. Initial and control endoscopic pathologies and Hp-positivity were compared. Results: In the control of 126 patients, 87 (69%) patients had a normal endoscopic appearance, but only 46 (36.5%) patients were normal in the histopathological examinations of biopsies. Regardless of the severity, complete eradication of Hp was possible in 31 (24.6%) patients. There was no statistically significant difference in Hp detection rates after treatment (p=0.719 for 1+, p=0.583 for 2+, p for 3+)=0.980). Conclusion: In gastritis cases, Hp positivity continues despite the treatment, although the pathological severity changes. It is appropriate to discuss the effectiveness of routine treatments and to take even bismuth to the forefront.