Association of AGTR1 gene methylation and its genetic variant in Chinese farmer with hypertension: A case-control study
Open Access
- 22 July 2022
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Medicine
- Vol. 101 (29), e29712
- https://doi.org/10.1097/md.0000000000029712
Abstract
The objective was to determine the potential associations of the angiotensin II receptor type 1 (AGTR1) gene polymorphism, methylation, and lipid metabolism in Chinese farmers with hypertension. A case-control study was conducted in Wuzhi county of Henan province in China in 2013 to 2014. A total of 1034 local residents (35–74 years, 386 hypertensive cases, and 648 normotensive subjects) were enrolled in this study. Triglyceride (TG), total cholesterol (TC), high-density lipoprotein, and low-density lipoprotein were measured using automatic chemistry analyzer. The AGTR1 gene promoter methylation level was measured using quantitative methylation-specific polymerase chain reaction method. The single nucleotide polymorphism rs275653 was genotyped with TaqMan probe assay at an applied biosystems platform. The gender, body mass index (BMI), TG, TC, and family history of hypertension in the hypertension group were significantly higher than those in control group (P < .05). No significant difference was observed in the distribution of AGTR1 rs275653 polymorphism in the hypertension and controls (P > .05). The AGTR1 gene methylation in subjects carrying different genotypes was not significantly observed (P > .05). The logistic regression analysis found the AGTR1 gene methylation level was negative correlation with hypertension in the present study (odds ratio, 0.946, 95% confidence interval, 0.896–0.999) through adjusting for age, gender, BMI, education, smoking, alcohol drinking, fruit and vegetable intake, pickles intake, and family history of hypertension. The association of AGTR1 gene hypomethylation and essential hypertension was observed in Chinese farmers; no significant difference was observed in the distribution of AGTR1 rs275653 polymorphism.Keywords
This publication has 25 references indexed in Scilit:
- Aging, Arterial Stiffness, and HypertensionHypertension, 2015
- Correlation of renin angiotensin system (RAS) candidate gene polymorphisms with response to Ramipril in patients with essential hypertensionJournal of Postgraduate Medicine, 2015
- Angiotensin type 1 and type 2 receptors during ontogeny: cardiovascular and renal effectsVascular Pharmacology, 2014
- Renal Generation of Angiotensin II and the Pathogenesis of HypertensionCurrent Hypertension Reports, 2014
- A polymorphism inAGTandAGTR1gene is associated with lead-related high blood pressureJournal of the Renin-Angiotensin-Aldosterone System, 2014
- Placental lipoprotein lipase DNA methylation levels are associated with gestational diabetes mellitus and maternal and cord blood lipid profilesJournal of Developmental Origins of Health and Disease, 2014
- Essential hypertension and oxidative stress: New insightsWorld Journal of Cardiology, 2014
- IGF2 Methylation Is Associated with Lipid Profile in Obese ChildrenHormone Research in Paediatrics, 2013
- The interaction ofAGTandNOS3gene polymorphisms with conventional risk factors increases predisposition to hypertensionJournal of the Renin-Angiotensin-Aldosterone System, 2012
- Global burden of hypertension: analysis of worldwide dataThe Lancet, 2005