Near-infrared fluorogenic receptor for selective detection of cysteine in blood serum and living cells
- 27 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Analytical and Bioanalytical Chemistry
- Vol. 413 (7), 1817-1826
- https://doi.org/10.1007/s00216-020-03149-8
Abstract
A novel near-infrared fluorescent probe, namely propane-2,2-diylbis(2-((E)-2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)-4,1-phenylene) diacrylate (BTA), was synthesized for selective detection of cysteine over other biologically significant amino acids. Upon addition of cysteine, the probe BTA displays a dramatic increase in fluorescence intensity at 715 nm along with a fast response time (4 min). The limit of detection (LOD) was calculated as 0.12 μM. In addition, the synthesized probe BTA was effectively utilized for the recognition of cysteine in blood serum and living cells. Graphical abstractKeywords
Funding Information
- University Grants Commission (540/20/DRS-I/2016(SAP-I)
- Department of Science and Technology, Ministry of Science and Technology, Government of India (INSPIRE scheme No. IF140098)
- Council of Scientific and Industrial Research (01 (2907)/17/EMR-II)
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