Assessment of the Phytochemical Analysis and Antimicrobial Potentials of Zingiber zerumbet
Open Access
- 3 January 2023
- Vol. 28 (1), 409
- https://doi.org/10.3390/molecules28010409
Abstract
Antimicrobial resistance (AMR) has arisen as a global concern in recent decades. Plant extracts used in combination with antibiotics are promising against AMR, synergistically. The purpose of this study was to evaluate the component of the bitter ginger (Zingiber zerumbet) extract in different solvents using high-performance liquid chromatography (HPLC), in addition to evaluate the antibacterial activity of these extracts, in combination with their antibiotic potential against four multi-drug resistant (MDR) bacterial strains (Lactobacillus acidophilus, Streptococcus mutans, Enterococcus faecalis and Staphylococcus aureus). Ethanol and the aqueous extracts of bitter ginger were prepared using a conventional solvent extraction method and were evaluated for their phytochemistry using HPLC, qualitatively and quantitatively. Moreover, the antibiotic susceptibility of the pathogenic isolates was determined. A disc diffusion assay was used to obtain the antimicrobial potential of the extracts alone and with antibiotics. Eight components were identified from the separation of the bitter ginger extract by HPLC. For AMR bacteria, the combination of the antibiotic solution with the bitter ginger crude extracts could improve its susceptibility of these antibiotics. This study indicates that the combination of an antibiotic solution with the bitter ginger crude extract exhibits potent antibacterial activities against MDR bacterial strains. Therefore, they can be used for the treatment of various diseases against the microbial pathogen and can be incorporated into medication for antibacterial therapy.Funding Information
- University of Central Punjab and Universiti Malaysia Sabah
This publication has 36 references indexed in Scilit:
- Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effectsJournal of the Science of Food and Agriculture, 2015
- Botanical alternatives to antibiotics for use in organic poultry productionPoultry Science, 2015
- Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) SmithPLOS ONE, 2015
- Strengthening of Oral Health Systems: Oral Health through Primary Health CareMedical Principles and Practice, 2014
- Acute and 28-Day Subchronic Oral Toxicity of an Ethanol Extract ofZingiber zerumbet(L.) Smith in RodentsEvidence-Based Complementary and Alternative Medicine, 2012
- Antiinflammatory and Antinociceptive Activities of Zingiber zerumbet Methanol Extract in Experimental Model SystemsMedical Principles and Practice, 2010
- Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: a study against gram-positive and gram-negative bacteriaNanomedicine: Nanotechnology, Biology and Medicine, 2010
- Acute Toxicity Study and Phytochemical Screening of Selected Herbal Aqueous Extract in Broiler ChickensInternational Journal of Pharmacology, 2008
- Ginger—An Herbal Medicinal Product with Broad Anti-Inflammatory ActionsJournal of Medicinal Food, 2005
- The phylogeny and a new classification of the gingers (Zingiberaceae): evidence from molecular dataAmerican Journal of Botany, 2002