Effect of perioperative aspirin continuation on bleeding after pneumonectomy
Open Access
- 13 March 2023
- journal article
- research article
- Published by Wiley in Thoracic Cancer
- Vol. 14 (12), 1071-1076
- https://doi.org/10.1111/1759-7714.14846
Abstract
Background: To investigate the effect of continuous oral aspirin in perioperative period on bleeding in pneumonectomy.Methods: A total of 170 patients who underwent pneumonectomy in our hospital from March 2021 to March 2022 were selected as the study objects. All patients took oral aspirin before surgery and did not take other antiplatelet agent or anticoagulants at the same time. The continuation group included 85 cases and continued to take aspirin 100 mg/day during the perioperative period, and the interruption group included 85 cases who stopped aspirin for 7 days before surgery and 3 days after surgery, without bridging therapy. The intraoperative blood loss, operation time, conversion to thoracotomy rate, postoperative bleeding rate, blood transfusion rate, thrombotic events, postoperative drainage volume, length of hospital stay, and total hospital cost of the two groups were compared.Results: There were no statistically significant differences in intraoperative blood loss, operative time, rate of conversion to open, postoperative drainage, hospital stay, and cost between the two groups (p > 0.05), and there were no reoperations due to bleeding between the two groups.Conclusions: Aspirin should be continued throughout the perioperative period in all high-risk patients requiring pneumonectomy after balancing ischemic-bleeding risks.Keywords
This publication has 25 references indexed in Scilit:
- Management of antiplatelet therapy in patients with coronary stents undergoing noncardiac surgery: association with adverse eventsBritish Journal of Anaesthesia, 2017
- Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac SurgeryAnnals of Internal Medicine, 2017
- 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTSEuropean Heart Journal, 2017
- Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac SurgeryJAMA, 2017
- Risk of Major Adverse Cardiac Events Following Noncardiac Surgery in Patients With Coronary StentsJAMA, 2013
- A randomised controlled pilot trial to evaluate and optimize the use of anti-platelet agents in the perioperative management in patients undergoing general and abdominal surgery—the APAP trial (ISRCTN45810007)Langenbecks Archiv für Chirurgie, 2011
- Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patientsBMJ, 2002
- Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial.2000
- Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trialThe Lancet, 2000
- AspirinJournal of the American College of Cardiology, 2000