Polyploidy in Tissue Repair and Regeneration
- 29 June 2021
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 13 (10), a040881
- https://doi.org/10.1101/cshperspect.a040881
Abstract
Polyploidy is defined as a cell with three or more whole genome sets and enables cell growth across the kingdoms of life. Studies in model organisms have revealed that polyploid cell growth can be required for optimal tissue repair and regeneration. In mammals, polyploid cell growth contributes to repair of many tissues, including the liver, heart, kidney, bladder, and eye, and similar strategies have been identified in Drosophila and zebrafish tissues. This review discusses the heterogeneity and versatility of polyploidy in tissue repair and regeneration. Polyploidy has been shown to restore tissue mass and maintain organ size as well as protect against oncogenic insults and genotoxic stress. Polyploid cells can also serve as a reservoir for new diploid cells in regeneration. The numerous mechanisms to generate polyploid cells provide an unlimited resource for tissues to exploit to undergo repair or regeneration.Keywords
This publication has 81 references indexed in Scilit:
- Canonical and atypical E2Fs regulate the mammalian endocycleNature, 2012
- Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regenerationProceedings of the National Academy of Sciences of the United States of America, 2012
- Polyploidization of glia in neural development links tissue growth to blood–brain barrier integrityGenes & Development, 2012
- Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycleNature Communications, 2012
- Control of Drosophila endocycles by E2F and CRL4CDT2Nature, 2011
- Developmental control of the DNA replication and transcription programsGenome Research, 2010
- The ploidy conveyor of mature hepatocytes as a source of genetic variationNature, 2010
- The Drosophila Hindgut Lacks Constitutively Active Adult Stem Cells but Proliferates in Response to Tissue DamageCell Stem Cell, 2009
- Endocycling cells do not apoptose in response to DNA rereplication genotoxic stressGenes & Development, 2008
- Heart Regeneration in ZebrafishScience, 2002