Aqueous Extract of Erythrina senegalensis Exhibits Dose-Dependent Hepatoprotective Activity on Paracetamol-Induced Liver Damage in Wistar Rats
Open Access
- 1 January 2022
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Advances in Biological Chemistry
- Vol. 12 (02), 48-60
- https://doi.org/10.4236/abc.2022.122005
Abstract
Erythrina senegalensis is utilized in the treatment of liver diseases in folklore medicine in most of northern Nigeria, but sufficient pharmacological-based and peer-reviewed scientific literature is not available to authenticate its use in the treatment of liver ailments. This research is aimed at assessing the hepatoprotective effects of Erythrina senegalensis against paracetamol-induced (PCM-induced) hepatotoxicity in wistar albino rats. This was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) as compared with the control group. The extract was concentrated and then desired concentrations of extracts were made by dissolving in normal saline. Four different doses of aqueous extracts Erythrina senegalensis (200, 300, 400 and 500 mg/kg) were administered orally for 6 consecutive days after the 72 hrs administration of paracetamol (1500 mg/kg) per body weight. Paracetamol significantly induced oxidative stress in the liver, ultimately leading to increased serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. Administration of the extracts showed significant (p 0.05) and dose-dependent hepatoprotective activity resulting in decrease in the activity of ALT, AST and ALP. These data revealed that Erythrina senegalensis aqueous extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.Keywords
This publication has 22 references indexed in Scilit:
- Role of curcumin in systemic and oral health: An overviewJournal of Natural Science, Biology and Medicine, 2013
- The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentationJCI Insight, 2012
- Protective Role ofFicus caricaStem Extract against Hepatic Oxidative Damage Induced by Methanol in Male Wistar RatsEvidence-Based Complementary and Alternative Medicine, 2011
- Hepatoprotective Effects ofOrthosiphon stamineusExtract on Thioacetamide-Induced Liver Cirrhosis in RatsEvidence-Based Complementary and Alternative Medicine, 2011
- Traditional Medicine: Past, present and future research and development prospects and integration in the National Health System of CameroonAfrican Journal of Traditional, Complementary and Alternative Medicines, 2011
- Protective Effects of Hyperoside against Carbon Tetrachloride-Induced Liver Damage in MiceJournal of Natural Products, 2011
- Prenylisoflavonoids fromErythrina senegalensisas Novel HIV-1 Protease InhibitorsPlanta Medica, 2008
- Ethnopharmacological uses of Erythrina senegalensis: a comparison of three areas in Mali, and a link between traditional knowledge and modern biological scienceJournal of Ethnobiology and Ethnomedicine, 2008
- Oral or Intravenous N-Acetylcysteine for Acetaminophen Poisoning?Annals of Emergency Medicine, 2005
- ACETAMINOPHEN-INDUCED HEPATOTOXICITYDrug Metabolism and Disposition, 2003