Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats
Open Access
- 27 October 2021
- journal article
- research article
- Published by Hindawi Limited in Oxidative Medicine and Cellular Longevity
- Vol. 2021, 1-14
- https://doi.org/10.1155/2021/9930187
Abstract
Ulcerative colitis (UC) is a common chronic nonspecific intestinal inflammation of unknown etiology associated with a low cure rate and a high relapse rate. Hair follicle mesenchymal stem cells (HF-MSCs) are a class of pluripotent stem cells that have differentiation potential and strong proliferation ability. Nuclear factor red system related factor (Nrf-2) is a key factor in the oxidative stress response. Dextran sulfate sodium- (DSS-) induced rat UC models closely mimic human UC in terms of symptoms and histological changes. Animals were divided into five groups, including a healthy group and UC model rats treated with normal saline, Nrf-2, HF-MSCs, or Nrf-2-expressing HF-MSC group. Based on the expression of intestinal stem cells, inflammatory factors, anti-inflammatory factors, and disease activity index scores, Nrf-2-expressing HF-MSCs had the most obvious therapeutic effect under the same treatment regimen. This study provided a new potential clinical treatment option for ulcerative colitis.Keywords
This publication has 39 references indexed in Scilit:
- The regulatory role of Nrf2 in antioxidants phase2 enzymes and IL-17A expression in patients with ulcerative colitisPathology - Research and Practice, 2018
- miR-10a rejuvenates aged human mesenchymal stem cells and improves heart function after myocardial infarction through KLF4Stem Cell Research & Therapy, 2018
- The limited application of stem cells in medicine: a reviewStem Cell Research & Therapy, 2018
- Transplantation with hypoxia‐preconditioned mesenchymal stem cells suppresses brain injury caused by cardiac arrest–induced global cerebral ischemia in ratsJournal of Neuroscience Research, 2017
- Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinomaOncotarget, 2017
- Preconditioning of Human Mesenchymal Stem Cells to Enhance Their Regulation of the Immune ResponseStem Cells International, 2016
- Restoring Mucosal Barrier Function and Modifying Macrophage Phenotype with an Extracellular Matrix Hydrogel: Potential Therapy for Ulcerative ColitisJournal of Crohn's and Colitis, 2016
- The Protective Effects of Isoliquiritigenin and Glycyrrhetinic Acid against Triptolide-Induced Oxidative Stress in HepG2 Cells Involve Nrf2 ActivationEvidence-Based Complementary and Alternative Medicine, 2016
- The Nrf2 regulatory network provides an interface between redox and intermediary metabolismTrends in Biochemical Sciences, 2014
- Mesenchymal stem cells reprogram host macrophages to attenuate obliterative bronchiolitis in murine orthotopic tracheal transplantationInternational Immunopharmacology, 2013