Effect of systemic immune inflammation index on symptom development in patients with moderate to severe carotid stenosis

Abstract
Background/Aim: Recent studies have shown that various inflammatory parameters obtained from routine blood tests can be used in the diagnosis and follow-up of cardiovascular diseases. Stroke is the second most common cause of death in the world. In this study, we aimed to investigate the role of systemic immune inflammation index (SII) value in predicting symptom development in patients with moderate to severe carotid artery stenosis (CAS). Methods: Patients between the ages of 41 and 94 with moderate to severe CAS who were followed up and treated electively in our clinic between October 01, 2016 and October 31, 2021 were included in this retrospective observational cohort study. A total of 314 consecutive patients were included in the study. The patients were divided into two groups as asymptomatic (Group 1) and symptomatic group (Group 2). Results: There were 245 and 69 patients in Groups 1 and 2, respectively. The median ages of patients in Groups 1 and 2 were 62 (41-86) years and 69 (49-94) years, respectively (P/g,""); st = st.replace(//g,""); st = st.replace(/<\/strong>/g,""); st = st.replace(/ /g,""); let title = "Background/Aim:"; if(st.includes(title)){ st = st.replace(title, ""+title+" "); } else{ title = "Aim:"; st = st.replace(title, ""+title+""); } let titles = ["Methods:", "Conclusion:", "Results:"]; titles.forEach((title, ndx) => { //console.log(title); st = st.replace(title, " "+title+""); }); //console.log(st); innerHTML = ''+st+''; }); Downloads Download data is not yet available. References Naghavi M, Abajobir AA, Abbafati C, Abbas KM, Abd-Allah F, Abera SF. GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1151-210. doi: 10.1016/S0140-6736(17)32152-9. Barnett HJ, Gunton RW, Eliasziw M, Fleming L, Sharpe B, Gates P, et al. Causes and severity of ischemic stroke in patients with internal carotid artery stenosis. JAMA. 2000 Mar 15;283(11):1429-36. doi: 10.1001/jama.283.11.1429. Kurtul A, Ornek E. Platelet to Lymphocyte Ratio in Cardiovascular Diseases: A Systematic Review. Angiology. 2019 Oct;70(9):802-18. doi: 10.1177/0003319719845186. Steven S, Frenis K, Oelze M, Kalinovic S, Kuntic M, Bayo Jimenez MT, et al. Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease. Oxid Med Cell Longev. 2019 Jun 23;2019:7092151. doi: 10.1155/2019/7092151. Haybar H, Pezeshki SMS, Saki N. Evaluation of complete blood count parameters in cardiovascular diseases: An early indicator of prognosis? ExpMolPathol. 2019 Oct;110:104267. doi: 10.1016/j.yexmp.2019.104267. Massiot N, Lareyre F, Voury-Pons A, Pelletier Y, Chikande J, Carboni J, et al. High Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are Associated with Symptomatic Internal Carotid Artery Stenosis. J Stroke Cerebrovasc Dis. 2019 Jan;28(1):76-83. doi: 10.1016/j.jstrokecerebrovasdis.2018.09.001. Engin M, Ozsin KK, Savran M, Guvenc O, Yavuz S, Ozyazicioglu AF. Visceral Adiposity Index and Prognostic Nutritional Index in Predicting Atrial Fibrillation after On-Pump Coronary Artery Bypass Operations: a Prospective Study. Braz J Cardiovasc Surg. 2021 Aug 6;36(4):522-9. doi: 10.21470/1678-9741-2020-0044 Engin M, Güvenç O. Investigation of the Predictive Values of Triglyceride/HDL Cholesterol Ratio and Whole Blood Viscosity with Regard to Severe Peripheral or Carotid Artery Disease in Patients Scheduled for Coronary Bypass. Heart Surg Forum. 2020 May 14;23(3):E310-E314. doi: 10.1532/hsf.2991. Erdolu B, Engin M. The effect of mean platelet volume-to-lymphocyte ratio on symptom onset in patients with carotid artery stenosis. Turk J Vasc Surg. 2021;30(1):7-12 doi: 10.9739/tjvs.2021.809 Lanzino G, Rabinstein AA, Brown RD Jr. Treatment of carotid artery stenosis: medical therapy, surgery, or stenting? Mayo Clin Proc. 2009 Apr;84(4):362-87; quiz 367-8. doi: 10.1016/S0025-6196(11)60546-6. Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr. 2006 Feb;83(2):456S-460S. doi: 10.1093/ajcn/83.2.456S. Engin M, Goncu MT. The role of plateletcrit and neutrophil lymphocyte ratio in showing the clinical severity of the disease in patients with chronic venous insufficiency. Ann Med Res 2020;27(5):1385-90 doi: 10.5455/annalsmedres.2019.12.866 Leclercq A, Houard X, Philippe M, Ollivier V, Sebbag U, Meilhac O et al. Involvement of intraplaque hemorrhage in atherothrombosis evolution via neutrophil protease enrichment. J Leukoc Biol. 2007 Dec;82(6):1420-9. doi: 10.1189/jlb.1106671. Nasr N, Ruidavets JB, Arnal JF, Sie P, Larrue V. Association of neutrophil count with microembolization in patients with symptomatic carotid artery stenosis. Atherosclerosis. 2009 Dec;207(2):519-23. doi: 10.1016/j.atherosclerosis.2009.05.003. Ionita MG, van den Borne P, Catanzariti LM, Moll FL, de Vries JP, Pasterkamp G, et al. High neutrophil numbers in human carotid...