Sepsis be considered health problems in infants in developing countries and industrialized countries. That is because sepsis has a mortality rate that is enough high on the infants. Lack of knowledge of parents to the sepsis causing treatment too late. This study attempted to show how the Dempster-Shafer method can be used to detect Sepsis disease in Infants. Dempster-Shafer method combines Trust Value of symptoms one by one. This method is a model uncertainty with a range of probabilities. The study used six symptoms on 5 kinds of different conditions of Trust Value from any symptoms. The trials applied using the programming language PHP and HTML. The results of Dempster-Shafer for Sepsis in Infants that Condition 1 is 0.66977, Condition 2 is 0.60435, Condition 3 is 0.69249, Condition 4 is 0.66132, and the Condition 5 is 0.76756.