Management of Streptococcus mutans-Candida spp. Oral Biofilms’ Infections: Paving the Way for Effective Clinical Interventions
Open Access
- 14 February 2020
- journal article
- review article
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 9 (2), 517
- https://doi.org/10.3390/jcm9020517
Abstract
Oral diseases are considered the most common noncommunicable diseases and are related to serious local and systemic disorders. Oral pathogens can grow and spread in the oral mucosae and frequently in biomaterials (e.g., dentures or prostheses) under polymicrobial biofilms, leading to several disorders such as dental caries and periodontal disease. Biofilms harbor a complex array of interacting microbes, increasingly unapproachable to antimicrobials and with dynamic processes key to disease pathogenicity, which partially explain the gradual loss of response towards conventional therapeutic regimens. New drugs (synthesized and natural) and other therapies that have revealed promising results for the treatment or control of these mixed biofilms are presented and discussed here. A structured search of bibliographic databases was applied to include recent research. There are several promising new approaches in the treatment of Candida spp.–Streptococcus mutans oral mixed biofilms that could be clinically applied in the near future. These findings confirm the importance of developing effective therapies for oral Candida–bacterial infections.This publication has 116 references indexed in Scilit:
- Antiadherent activity of Schinus terebinthifolius and Croton urucurana extracts on in vitro biofilm formation of Candida albicans and Streptococcus mutansArchives of Oral Biology, 2014
- Photosensitization of in vitro biofilms formed on denture base resinThe Journal of Prosthetic Dentistry, 2014
- Cross-feeding and interkingdom communication in dual-species biofilms of Streptococcus mutans and Candida albicansThe ISME Journal, 2014
- Symbiotic Relationship between Streptococcus mutans and Candida albicans Synergizes Virulence of Plaque Biofilms In VivoInfection and Immunity, 2014
- Structure, function and diversity of the healthy human microbiomeNature, 2012
- The Human Oral MicrobiomeJournal of Bacteriology, 2010
- Streptococcus mutans, Caries and Simulation ModelsNutrients, 2010
- Associations between periodontal diseases and systemic diseases: A review of the inter-relationships and interactions with diabetes, respiratory diseases, cardiovascular diseases and osteoporosisPublic Health, 2008
- Amyloid-Like Adhesins Produced by Floc-Forming and Filamentous Bacteria in Activated SludgeApplied and Environmental Microbiology, 2008
- Periodontal diseasesThe Lancet, 2005