Anodic Stripping Voltammetric Methods for Determination of Brexpiprazole and its Elec-Trochemical Oxidation Behavior in Pure Form and Pharmaceutical Preparations

Abstract

The voltammetric behavior of brexpiprazole (BRX) was studied using cyclic voltammetry (CV), anodic stripping differential pulse (AS-DP) and anodic stripping square wave (AS-SWT) voltammetry at novel functionalized carbon paste electrode (FCPEs). Electrochemical oxidation behavior of brexpiprazole shows irreversible anodic peak at 0.87 V versus Ag/AgCl, in Britton-Robinson buffer (BR) at pH 4.0, 50s preconcetration time and -0.5 deposition potential. The peak current concentration relationship was rectilinear over the ranges of 6.64 x 10(-7) -3.2 x 10(-6) and 6.64 x 10(-8) 3.2 x 10(-7) mol L-1 with a minimum detection limit of 1.74 x 10(-7) and 1.32 x 10(-8) mol L-1 for AS-DP and AS-SWV respectively, The proposed methods have been applied successfully for the analysis of the drug in pure and in its dosage forms.