Evaluation of the potential use of poly(ethylene oxide) as tablet- and extrudate-forming material
- 1 June 2004
- journal article
- research article
- Published by Springer Science and Business Media LLC in AAPS PharmSci
- Vol. 6 (2), 17-26
- https://doi.org/10.1208/ps060215
Abstract
The purpose of this study was to assess the potential use of poly(ethylene oxide) (PEO) as matrix-forming mate-rial for tablets and extrudates. Raw materials were characterized for size, size distribution, and shape. Tablets with 2- and 10-mm diameter were prepared by direct compression at both 13 and 38 MPa from mixtures with poly(ethylene oxide)s, a model drug (propranolol hydrochloride) and lactose. To these mixtures water was added (16%–43%) prior to extrusion in a ram extruder fit with different dies (1-, 3-, 6-, and 9-mm diameter and 4-mm length). Tablets and extrudates were characterized for work of compression or extrusion, respectively, relaxation, tensile strength, friability, and drug release. Both PEOs produced tablets easily and with different properties. Some relaxation was observed, particularly for tablets with higher amounts of PEOs. Release of the drug occurred after swelling of the matrix, and between 10% and 70% drug released, a quasi zero-order release was observed for large tablets. Extrusion was possible for formulations with PEO only with amounts of water between 16% and 50%. Both radial and axial relaxation of both plugs and extrudates were observed. Moreover, different extrusion profiles reflected the different behaviors of the different formulations. The model drug was released in the same fashion as observed for the tablets. It was possible to produce tablets by direct compression and extrudates or pellets from those extrudates from different formulations with PEO. Tablets and pellets have shown distinct properties depending upon the PEO considered. Extrusion was particularly complex with different formulations with PEO.Keywords
This publication has 15 references indexed in Scilit:
- Production and Characterization of Hot-Melt Extruded Films Containing ClotrimazoleDrug Development and Industrial Pharmacy, 2003
- Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusionBiomaterials, 2002
- Co‐extrusion of biocompatible polymers for scaffolds with co‐continuous morphologyJournal of Biomedical Materials Research, 2002
- Release of Cyclobenzaprine Hydrochloride from Osmotically Rupturable TabletsDrug Development and Industrial Pharmacy, 2002
- Interactions in poly(ethylene oxide)–hydroxypropyl methylcellulose blendsPolymer, 2001
- Development and Evaluation of oral multiple-unit and single-unit hydrophilic controlled-release systemsAAPS PharmSciTech, 2000
- Influence of Vitamin E TPGS on the properties of hydrophilic films produced by hot-melt extrusionInternational Journal of Pharmaceutics, 2000
- Compaction simulator study of a novel triple-layer tablet matrix for industrial tabletingInternational Journal of Pharmaceutics, 1997
- Drug Release from Compressed Hydrophilic POLYOX‐WSR TabletsJournal of Pharmaceutical Sciences, 1995
- Determination of Tablet Strength by the Diametral-Compression TestJournal of Pharmaceutical Sciences, 1970