The rapid adaptation of SARS-CoV-2–rise of the variants: transmission and resistance
- 27 August 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Microbiology
- Vol. 59 (9), 807-818
- https://doi.org/10.1007/s12275-021-1348-5
Abstract
The causative factor of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating. Interestingly, identified mutations mainly occur in the spike (S) protein which interacts with the ACE2 receptor and is cleaved via serine protease TMPRSS2. Some mutated strains are becoming dominant in various parts of the globe because of increased transmissibility as well as cell entry efficacy. Remarkably, the neutralizing activity of monoclonal antibodies, convalescent sera, and vaccines against the variants has been reported to be significantly reduced. Therefore, the efficacy of various monoclonal antibodies therapy and vaccines against these variants is becoming a great global concern. We herein summarize the current status of SARS-CoV-2 with gears shifted towards the recent and most common genetic variants in relation to transmission, neutralizing activity, and vaccine efficacy.Keywords
This publication has 138 references indexed in Scilit:
- Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factorsNature Communications, 2019
- Coronaviruses: An Overview of Their Replication and PathogenesisPublished by Springer Science and Business Media LLC ,2015
- Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirusVirus Research, 2014
- Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule InhibitionCell, 2011
- Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63Journal of Virology, 2010
- The Molecular Biology of CoronavirusesPublished by Elsevier BV ,2006
- Dynasore, a Cell-Permeable Inhibitor of DynaminDevelopmental Cell, 2006
- Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and humanProceedings of the National Academy of Sciences of the United States of America, 2005
- Multiple Enzymatic Activities Associated with Severe Acute Respiratory Syndrome Coronavirus HelicaseJournal of Virology, 2004
- Graft HemostasisThe Annals of Thoracic Surgery, 1981