Organelle-specific regulation of ferroptosis
- 31 August 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell Death & Differentiation
- Vol. 28 (10), 2843-2856
- https://doi.org/10.1038/s41418-021-00859-z
Abstract
Ferroptosis, a cell death modality characterized by iron-dependent lipid peroxidation, is involved in the development of multiple pathological conditions, including ischemic tissue damage, infection, neurodegeneration, and cancer. The cellular machinery responsible for the execution of ferroptosis integrates multiple pro-survival or pro-death signals from subcellular organelles and then ‘decides’ whether to engage the lethal process or not. Here, we outline the evidence implicating different organelles (including mitochondria, lysosomes, endoplasmic reticulum, lipid droplets, peroxisomes, Golgi apparatus, and nucleus) in the ignition or avoidance of ferroptosis, while emphasizing their potential relevance for human disease and their targetability for pharmacological interventions.Keywords
This publication has 183 references indexed in Scilit:
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell DeathCell, 2012
- Protein Folding and Modification in the Mammalian Endoplasmic ReticulumAnnual Review of Biochemistry, 2011
- The role of the Golgi apparatus in oxidative stress: is this organelle less significant than mitochondria?Free Radical Biology & Medicine, 2011
- Short Form Glutathione Peroxidase 4 Is the Essential Isoform Required for Survival and Somatic Mitochondrial FunctionsOnline Journal of Public Health Informatics, 2009
- Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytesJournal of Cellular Biochemistry, 2008
- Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell DeathCell Metabolism, 2008
- RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channelsNature, 2007
- Gpx4 protects mitochondrial ATP generation against oxidative damageBiochemical and Biophysical Research Communications, 2007
- Mitochondrial Membrane Permeabilization in Cell DeathPhysiological Reviews, 2007
- Bcl-2 blocks apoptosis in cells lacking mitochondrial DNANature, 1993