The search for novel analgesics: targets and mechanisms
Open Access
- 26 May 2015
- journal article
- review article
- Published by H1 Connect in F1000Prime Reports
- Vol. 7 (56), 56
- https://doi.org/10.12703/p7-56
Abstract
The management of the pain state is of great therapeutic relevance to virtually every medical specialty. Failure to manage its expression has deleterious consequence to the well-being of the organism. An understanding of the complex biology of the mechanisms underlying the processing of nociceptive information provides an important pathway towards development of novel and robust therapeutics. Importantly, preclinical models have been of considerable use in determining the linkage between mechanism and the associated behaviorally defined pain state. This review seeks to provide an overview of current thinking targeting pain biology, the use of preclinical models and the development of novel pain therapeutics. Issues pertinent to the strengths and weaknesses of current development strategies for analgesics are considered.This publication has 100 references indexed in Scilit:
- Why Most Published Research Findings Are FalsePLoS Medicine, 2005
- Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic painPain, 2005
- Transmucosal macromolecular drug deliveryJournal of Controlled Release, 2005
- Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the ratGene Therapy, 2004
- Opioid receptor binding and in vivo antinociceptive activity of position 3-substituted morphiceptin analogsBiochemical and Biophysical Research Communications, 2004
- Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic painNature, 2003
- Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured ratsPain, 2000
- Characterization of a rat model of incisional painPain, 1996
- Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using .omega.-conotoxin from Conus magus venomBiochemistry, 1987
- Ethical guidelines for investigations of experimental pain in conscious animalsPain, 1983