This study aims to identify the relationship between coping mechanisms and the level of depression in patients with diabetes mellitus. This research method uses a cross-sectional approach. The results showed a relationship between the testing mechanism and the level of depression in patients with diabetes mellitus with a p-value = 0.000. Multiple logistic regression analysis was also performed to determine the most influential variable on the level of depression. It was found that coping mechanisms were predictors of depression (B = (2,158). ), SE=0.587, Wald=13,500, p value= 0.000. In conclusion, coping mechanisms are related to the level of depression. People with diabetes who use good coping mechanisms are stabbed eight times experience mild depression. People with diabetes exercise when experiencing problems well, using good coping mechanisms good. Keywords: Diabetes Mellitus, Coping Mechanism, Depression Level