FIBROBLAST GROWTH FACTOR 23 AS EARLY MARKER OF MINERAL AND BONE DISORDER IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Abstract

The aim: to study the state of regulation of mineral metabolism in CKD by evaluating the serum concentration of c-terminal FGF-23, PTH, Ca, P, and to investigate the relationship between FGF-23 and PTH in CKD. Materials and methods. The study involved 106 people with CKD, 47women (44%) and 59men (56%) aged (49.6 ± 13.9) years. The C-terminal FGF-23 fragment was determined using a set of reagents for the enzyme immunoassay «Biomedica». The glomerular filtration rate (GFR) was calculated using the CKD EPI formula (KDIGO 2012). Results. A progressive increase in PTH levels was observed in parallel with the development of renal insufficiency in patients with CKD. Beginning with the CKD stage III, a significant increase above the norm (p