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FIBROBLAST GROWTH FACTOR 23 AS EARLY MARKER OF MINERAL AND BONE DISORDER IN PATIENTS WITH CHRONIC KIDNEY DISEASE

M. I. Chaikovska, L. P. Martynyuk
Ukrainian Journal of Nephrology and Dialysis pp 44-47; doi:10.31450/ukrjnd.1(57).2018.04

Abstract: The aim: to study the state of regulation of mineral metabolism in CKD by evaluating the serum concentration of c-terminal FGF-23, PTH, Ca, P, and to investigate the relationship between FGF-23 and PTH in CKD. Materials and methods. The study involved 106 people with CKD, 47women (44%) and 59men (56%) aged (49.6 ± 13.9) years. The C-terminal FGF-23 fragment was determined using a set of reagents for the enzyme immunoassay «Biomedica». The glomerular filtration rate (GFR) was calculated using the CKD EPI formula (KDIGO 2012). Results. A progressive increase in PTH levels was observed in parallel with the development of renal insufficiency in patients with CKD. Beginning with the CKD stage III, a significant increase above the norm (p
Keywords: chronic kidney disease / patients / PTH / CKD / mineral / Serum Concentration / Significant Increase / terminal FGF

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