Abstract: The syndesmosis ligament is a soft tissue complex that provides flexibility and stability to the ankle joint. These ligaments maintain stability between the distal tibia and the fibula. When these ligaments break in a severe ankle sprain, the distal fibula migrates and can no longer provide a stable lateral support to the ankle. The importance of accurate simultaneous reduction and fixation after distal tibiofibular syndesmosis injury has been proven. The gold standard for surgical treatment of distal tibiofibular syndesmosis injury is still fixation of the fibula to the tibia with screws, but there are many controversies regarding the position, quantity, size and number of penetrating cortex of screws. With the development of finite-element technology, the reliability of the finite-element model of the ankle joint established by this technology has been widely confirmed. More and more scholars have applied this technology to study the condition of screw fixation of the tibiofibular syndesmosis injury. Therefore, this paper mainly reviews the study of screw fixation tibiofibular injury by finite element method.