Evaluation of Sarcopenia Using Biomarkers of the Neuromuscular Junction in Parkinson’s Disease
- 19 January 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Molecular Neuroscience
- Vol. 72 (4), 820-829
- https://doi.org/10.1007/s12031-022-01970-7
Abstract
Patients with Parkinson’s disease (PD) present with an advanced form of age-related muscle loss or sarcopenia. However, the search for a biomarker to accurately predict muscle loss in PD remains elusive. We evaluated the biomarkers of neuromuscular junction (NMJ) stability, including c-terminal agrin fragment-22 (CAF22), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) as predictors of muscle wasting and physical capacity in PD. Male, 63—78 years patients of PD, were investigated for physical capacity, handgrip strength (HGS), and circulating biomarkers at the diagnosis and follow-up during rehabilitation 6 months apart. Patients with PD presented with elevated CAF22 and reduced BDNF and GDNF levels, which were partially restored to normal levels with rehabilitation. All three biomarkers showed significant dynamic associations with HGS and indexes of sarcopenia. Logistic regression revealed that the combination of biomarkers levels into a cumulative risk score enhanced the diagnostic accuracy of sarcopenia. In brief, measurements of plasma BDNF, GDNF, and CAF22 may be helpful in timely diagnosis and/or evaluation of sarcopenia.Keywords
Funding Information
- University of Sharjah (1901090168)
- University of Sharjah (1901090157, 2001090177)
This publication has 34 references indexed in Scilit:
- Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotypeRedox Biology, 2015
- Parkinson's disease severity levels and MDS-Unified Parkinson's Disease Rating ScaleParkinsonism & Related Disorders, 2015
- Effects of physical activity in Parkinson's disease: A new tool for rehabilitationWorld Journal of Methodology, 2014
- World Medical Association Declaration of HelsinkiJAMA, 2013
- C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junctionExperimental Gerontology, 2012
- Elevated levels of a C-terminal agrin fragment identifies a new subset of sarcopenia patientsExperimental Gerontology, 2012
- The Recent Understanding of the Neurotrophin's Role in Skeletal Muscle AdaptationJournal of Biomedicine and Biotechnology, 2011
- Receiver Operating Characteristic Curve in Diagnostic Test AssessmentJournal of Thoracic Oncology, 2010
- Long‐term changes in neurotrophic factor expression in distal nerve stump following denervation and reinnervation with motor or sensory nerveJournal of Neurochemistry, 2008
- HDL-cholesterol and physical performance: results from the ageing and longevity study in the sirente geographic area ( ilSIRENTE Study)Age and Ageing, 2007