Analytical Study on Relationship between Cell-Free Plasma DNA Concentration and Clinicopathological Features in Breast Cancer

Abstract

Background: Breast cancer is the most fatal form of cancer for female population and non-invasive method for early detection of human cancers is a promising way to provide more quality health service to the population. Objectives: In this study, we made basic data that can evaluate the progression of breast cancer by explaining the relationship between cell-free plasma DNA concentration and clinicopathological features in breast cancer. Methods: Cell free DNA levels were measured in plasma of breast cancer, breast benign disease and healthy people. Results: Cell-free plasma DNA concentration in breast cancer was significantly higher than in healthy individuals and breast benign disease. (pConclusion: Plasma free DNA concentration is related to progression and metastasis and it can be used as a remarkable biomarker to assess progression of breast cancer, lymph node metastasis and effect of the operation.