A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment
Open Access
- 22 May 2020
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 11, 996
- https://doi.org/10.3389/fimmu.2020.00996
Abstract
Food allergy is rising at an alarming rate and is a major public health concern. Globally, food allergy affects over 500 million people, often starting in early childhood and increasingly reported in adults. Commercially, only one approved oral immunotherapy-based treatment is currently available and other allergen-based immunotherapeutic are being investigated in clinical studies. As an alternative approach, a substantial amount of research has been conducted on natural compounds and probiotics, focusing on the immune modes of action, and therapeutic uses of such sources to tackle various immune-related diseases. Food allergy is primarily mediated by IgE antibodies and the suppression of allergic symptoms seems to be mostly modulated through a reduction of allergen-specific IgE antibodies, upregulation of blocking IgG, and downregulation of effector cell activation (e.g., mast cells) or expression of T-helper 2 (Th-2) cytokines. A wide variety of investigations conducted in small animal models or cell-based systems have reported on the efficacy of natural bioactive compounds and probiotics as potential anti-allergic therapeutics. However, very few lead compounds, unlike anti-cancer and anti-microbial applications, have been selected for clinical trials in the treatment of food allergies. Natural products or probiotic-based approaches appear to reduce the symptoms and/or target specific pathways independent of the implicated food allergen. This broad range therapeutic approach essentially provides a major advantage as several different types of food allergens can be targeted with one approach and potentially associated with a lower cost of development. This review provides a brief overview of the immune mechanisms underlying food allergy and allergen-specific immunotherapy, followed by a comprehensive collection of current studies conducted to investigate the therapeutic applications of natural compounds and probiotics, including discussions of their mode of action and immunological aspects of their disease-modifying capabilities.Funding Information
- National Health and Medical Research Council (GNT1086656, GNT1124143)
This publication has 176 references indexed in Scilit:
- The immune modifying effects of amino acids on gut-associated lymphoid tissueJournal of Animal Science and Biotechnology, 2013
- Oral supplementation with areca-derived polyphenols attenuates food allergic responses in ovalbumin-sensitized miceBMC Complementary and Alternative Medicine, 2013
- Allergen immunotherapy: routes, safety,efficacy, and mode of actionImmunoTargets and Therapy, 2013
- Bacteria of the human gut microbiome catabolize red seaweed glycans with carbohydrate-active enzyme updates from extrinsic microbesProceedings of the National Academy of Sciences of the United States of America, 2012
- Chinese herbal extracts of Rubia cordifolia and Dianthus superbus suppress IgE production and prevent peanut-induced anaphylaxisChinese Medicine, 2011
- Mast cell proteases and inflammationDrug Discovery Today: Disease Models, 2011
- IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signalingJournal of Allergy and Clinical Immunology, 2011
- Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free miceBMC Immunology, 2008
- Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cellsClinical and Experimental Immunology, 2008
- An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune SystemCell, 2005