Impact of Prediabetes on Cardiac Function Among Primary Care Patients
- 1 August 2023
- journal article
- research article
- Published by Mary Ann Liebert Inc in Metabolic Syndrome and Related Disorders
- Vol. 21 (6), 314-318
- https://doi.org/10.1089/met.2021.0006
Abstract
Background: Prediabetes is a novel risk factor recently associated with changes in the left ventricle. Our aim is to determine if prediabetes is associated with heart failure (HF) and structural heart disease. Methods: We conducted a cross-sectional study and performed screening echocardiograms to consecutive primary care patients. We calculated the hemoglobin A1c (HbA1c) within 3 months of the echocardiogram and classified patients as having normal glucose, low-risk or high-risk prediabetes or diabetes. Our primary outcome was HF defined as an ejection fraction (EF) Results: We included 15,056 patients who underwent a screening echocardiogram and had a recorded HbA1c. Only 2794 patients had a normal blood glucose, 4201 had low-risk prediabetes, 2499 had high-risk prediabetes, and the remainder had diabetes. The adjusted odds ratio (ORs) of HF for low-risk prediabetes, high-risk prediabetes and diabetes were 1.38 [confidence interval (95% CI) 1.07–1.78] (P = 0.01), 1.47 (95% CI 1.05–2.01) (P = 0.01), and 1.60 (95% CI 1.16–2.01) (P < 0.01), respectively, when compared with normoglycemic patients. The adjusted OR of HF with preserved EF for low- and high-risk prediabetes and diabetes were 1.17 (95% CI 0.86–1.60) (P = 0.30), 1.60 (95% CI 1.15–2.21) (P < 0.01), and 1.63 (95% CI 1.24–2.13) (P < 0.01), respectively, when compared with normoglycemic patients. Conclusions: Prediabetes is a prevalent condition associated with structural heart disease and HF.Keywords
This publication has 14 references indexed in Scilit:
- Cardiac Structure and Function Across the Glycemic Spectrum in Elderly Men and Women Free of Prevalent Heart DiseaseCirculation: Heart Failure, 2015
- Diabetes Mellitus, Prediabetes, and Incidence of Subclinical Myocardial DamageJournal of the American College of Cardiology, 2014
- Secular Changes in U.S. Prediabetes Prevalence Defined by Hemoglobin A1c and Fasting Plasma GlucoseDiabetes Care, 2013
- Innovations At Miami Practice Show Promise For Treating High-Risk Medicare PatientsHealth Affairs, 2013
- Preventing Type 2 Diabetes in Communities Across the U.S.: The National Diabetes Prevention ProgramAmerican Journal of Preventive Medicine, 2013
- The Identification of Prediabetes Condition with ARIC Algorithm Predicts Long-Term CV Events in Patients with Erectile DysfunctionThe Journal of Sexual Medicine, 2013
- Atrial Fibrillation and Outcomes in Heart Failure With Preserved Versus Reduced Left Ventricular Ejection FractionJournal of the American Heart Association, 2013
- Systematic Review of Comorbidity Indices for Administrative DataMedical Care, 2012
- American Society of Echocardiography recommendations for use of echocardiography in clinical trials: A report from the american society of echocardiography's guidelines and standards committee and the task force on echocardiography in clinical trialsJournal of the American Society of Echocardiography, 2004
- Burden of Systolic and Diastolic Ventricular Dysfunction in the CommunityJAMA, 2003