The Pharmacological Effects of Triterpenoids from Ganoderma lucidum and the Regulation of Its Biosynthesis
Open Access
- 1 January 2020
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Advances in Biological Chemistry
- Vol. 10 (02), 55-65
- https://doi.org/10.4236/abc.2020.102005
Abstract
Ganoderma lucidum is a wildly used medicinal mushroom and has been used in East Asia because of its health-benefit effects. G. lucidum contains various compounds with different biological activities, which include anti-tumour, anti-viral, and anti-malaria effect. Ganoderic acid (GA) is a triterpenoid from G. lucidum. The biosynthesis of GA in G. lucidum is induced by stressors including various elicitors or signaling molecules, and artificially placing elicitors would enhance GA production. In this paper, bioactivities and potential applications of GAs would be focused, and the elicitation strategies for GA production are also highlighted based on the fundamental role of ROS, JA, Ca2+ and NO, which would shed light to developing a novel approach to manipulating the biosynthesis of GA in the future.Keywords
This publication has 56 references indexed in Scilit:
- The emergence of drug resistant HIV variants and novel anti–retroviral therapyAsian Pacific Journal of Tropical Biomedicine, 2013
- A Novel Approach to Enhancing Ganoderic Acid Production by Ganoderma lucidum Using Apoptosis InductionPLOS ONE, 2013
- Enhancement of Ganoderic Acid Accumulation by Overexpression of an N-Terminally Truncated 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene in the Basidiomycete Ganoderma lucidumApplied and Environmental Microbiology, 2012
- Genome sequence of the model medicinal mushroom Ganoderma lucidumNature Communications, 2012
- Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPABiochemical and Biophysical Research Communications, 2011
- Development of a simple and efficient transformation system for the basidiomycetous medicinal fungus Ganoderma lucidumWorld Journal of Microbiology and Biotechnology, 2011
- Multi-fed batch culture integrated with three-stage light irradiation and multiple additions of copper ions for the hyperproduction of ganoderic acid and Ganoderma polysaccharides by the medicinal mushroom Ganoderma lucidumProcess Biochemistry, 2010
- Artemisinin Resistance inPlasmodium falciparumMalariaThe New England Journal of Medicine, 2009
- Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cellsLife Sciences, 2006
- Triterpenes from the Spores of Ganoderma lucidum and Their Inhibitory Activity against HIV-1 Protease.CHEMICAL & PHARMACEUTICAL BULLETIN, 1998