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Rapid Detection of Eszopiclone by Nanosilver Surface-Enhanced Raman Spectroscopy

严 硕
Published: 1 January 2021

Abstract: 目的:建立安眠药中非法添加艾司唑仑的表面增强拉曼光谱分析方法。方法:利用正交实验确定最佳检出条件,结合拉曼图谱对艾司唑仑的特征峰进行分析,建立艾司唑仑快速检测的定性定量识别模型。结论:以艾司唑仑683 cm−1处的特征峰强度建立标准曲线方程,检出限为0.1 μg∙mL−1。本方法的简便操作和较低成本为现场快速检验安眠药中艾司唑仑非法添加成分提供了新方法。 Objective: To establish a surface-enhanced Raman spectroscopy method for the analysis of illegally added eszopiclone in sleeping pills. Methods: To determine the best detection conditions using orthogonal experiments, to analyze the characteristic peaks of eszopiclone in combination with Raman mapping, and to establish a qualitative and quantitative identification model for the rapid detection of eszopiclone. Conclusion: A standard curve equation was established with the characteristic peak intensity of eszopiclone at 683 cm−1, and the detection limit was 0.1 μg∙mL−1. The simple operation and low cost of this method provide a new method for the rapid on-site inspection of the illegal addition of eszopiclone in sleeping pills.

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