New opportunities for preoperative diagnosis of anaplastic thyroid cancer
Open Access
- 24 April 2021
- journal article
- Published by Publishing House ABV Press in Head and Neck Tumors (HNT)
- Vol. 11 (1), 34-40
- https://doi.org/10.17650/2222-1468-2021-11-1-34-40
Abstract
Background. Anaplastic thyroid cancer (ATC) is one of the most aggressive human tumors. Since median survival of ATC patients is only 4 months, its early diagnosis is very important. Although ATC has specific clinical manifestations, the analysis of expression of different microRNAs can facilitate preoperative diagnostics and help to detect its potential precursors among differentiated cancers and other thyroid malignancies.The study objective is to identify microRNAs specific for ATC that are different from microRNAs in other thyroid cancers.Materials and methods. We analyzed the expression of 14 microRNAs in histological specimens of 67 patients with ATC. The control groups included 25 patients with benign nodules, 36 patients with follicular adenomas, 32 patients with follicular cancer, and 152 patients with papillary thyroid cancer. For 7 out of 67 ATC patients, we compared mi-croRNA levels in histological and cytological specimens.Results. Patients with ATC demonstrated a statistically significant decrease in the expression of miR-145, miR-125b and increase in the expression of miR-155 and miR-21 compared to all control groups. We found two reliable diagnostic markers of ATC: relative miR-21 expression (at a cutoff of 14.9, sensitivity was 0.955 and specificity was 0.837) and the miR-21/miR-145 ratio (at a cutoff of 122, sensitivity was 0.955 and specificity was 0.955). The level of miR-21 expression and miR-21/miR-145 ratio in cytological specimens were accurate in all 7 cases (100 %).Conclusion. the level of expression of specific microRNAs can be used as a reliable biomarker for ATC. The consistency between the results obtained in cytological and histological specimens enables the use of stained cytological samples for this analysis.Keywords
This publication has 11 references indexed in Scilit:
- Differential MicroRNA-Signatures in Thyroid Cancer SubtypesJournal of Oncology, 2020
- Preoperative detection of malignancy in fine-needle aspiration cytology (FNAC) smears with indeterminate cytology (Bethesda III, IV) by a combined molecular classifierJournal of Clinical Pathology, 2020
- Molecular Classification of Thyroid Nodules with Indeterminate Cytology: Development and Validation of a Highly Sensitive and Specific New miRNA-Based Classifier Test Using Fine-Needle Aspiration Smear SlidesThyroid®, 2018
- Genetic testing for indeterminate thyroid cytology: review and meta-analysisEndocrine-Related Cancer, 2018
- Integrated Analysis of Thyroid Cancer Public Datasets Reveals Role of Post-Transcriptional Regulation on Tumor Progression by Targeting of Immune System MediatorsPLOS ONE, 2015
- Marginal treatment benefit in anaplastic thyroid cancerCancer, 2013
- American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid CancerThyroid®, 2012
- Thyroid cancer stem cellsNature Reviews Endocrinology, 2011
- MicroRNA Expression Profiling of Thyroid Tumors: Biological Significance and Diagnostic UtilityJournal of Clinical Endocrinology & Metabolism, 2008
- Poorly Differentiated and Anaplastic Thyroid CancerCancer Control, 2006