Protein powder supplementation in early pregnancy and the risk of gestational diabetes mellitus: a prospective cohort study
- 22 March 2023
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Food & Function
- Vol. 14 (8), 3815-3823
- https://doi.org/10.1039/d2fo03609f
Abstract
Objective: Protein powder has attracted attention due to its possible adverse effects. We aimed to investigate the association of protein powder supplementation in early pregnancy with gestational diabetes mellitus (GDM) risk. Methods: We included 6897 participants with singleton pregnancies from a prospective birth cohort. Protein powder supplementation and GDM relationships were examined by unadjusted and multivariable analysis, 1 : 2 propensity score matching, and inverse probability weighting (IPW). A multinomial logistic regression model was used to further explore the effects of protein powder supplementation on the risk of GDM subtypes. Results: Overall, 14.6% of pregnant women (1010) were diagnosed with GDM. In the crude and multivariable analysis before propensity score matching, participants who had received protein powder supplements were more likely to have GDM than women who did not (OR, 1.39 [95% CI: 1.07–1.79]; OR, 1.32 [95% CI: 1.01–1.72]). Protein powder supplementation was significantly associated with a higher GDM risk on IPW analysis (OR, 1.41 [95% CI, 1.08–1.83]), propensity score matching analysis (OR, 1.40 [95% CI, 1.01–1.93]) and multivariable analysis adjusted for propensity score (OR, 1.53 [95% CI, 1.10–2.12]). In the multinomial logistic regression model, protein powder supplementation was only positively associated with the risk of GDM with isolated fasting hyperglycaemia (IFH) in the crude and multivariable models (OR, 1.87 [95% CI: 1.29–2.73]; OR, 1.82 [95% CI: 1.23–2.68]). Conclusions: Protein powder supplementation in early pregnancy is significantly associated with a greater risk of GDM, especially for GDM-IFH. Additional comparative studies are needed to validate these findings.Funding Information
- Health and Family Planning Commission of Wuhan Municipality (WG21D06)
This publication has 34 references indexed in Scilit:
- Protein and Amino Acid Requirements during PregnancyAdvances in Nutrition: An International Review Journal, 2016
- Risk factors for gestational diabetes: is prevention possible?Diabetologia, 2016
- Exposure to organophosphorus and organochlorine pesticides, perfluoroalkyl substances, and polychlorinated biphenyls in pregnancy and the association with impaired glucose tolerance and gestational diabetes mellitus: The MIREC StudyEnvironmental Research, 2016
- Relationship Between Insulin Resistance and β-Cell Dysfunction in Subphenotypes of Prediabetes and Type 2 DiabetesJournal of Clinical Endocrinology & Metabolism, 2015
- Introduction of IADPSG Criteria for the Screening and Diagnosis of Gestational Diabetes Mellitus Results in Improved Pregnancy Outcomes at a Lower Cost in a Large Cohort of Pregnant Women: The St. Carlos Gestational Diabetes StudyDiabetes Care, 2014
- Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trialDiabetologia, 2014
- Trajectories of cardiometabolic risk factors before diagnosis of three subtypes of type 2 diabetes: a post-hoc analysis of the longitudinal Whitehall II cohort studyThe Lancet Diabetes & Endocrinology, 2013
- The effect of different protein hydrolysate/carbohydrate mixtures on postprandial glucagon and insulin responses in healthy subjectsEuropean Journal of Clinical Nutrition, 2007
- An increase in dietary protein improves the blood glucose response in persons with type 2 diabetesThe American Journal of Clinical Nutrition, 2003
- Plasma Glucagon and Insulin Responses Depend on the Rate of Appearance of Amino Acids after Ingestion of Different Protein Solutions in HumansJournal of Nutrition, 2002