Antimicrobial Effect of Skin for Allograft and Management in Burn Wound
Open Access
- 1 January 2017
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Open Journal of Organ Transplant Surgery
- Vol. 07 (01), 1-11
- https://doi.org/10.4236/ojots.2017.71001
Abstract
One of the most important functions of skins is to protect our bodies from microbes or pollutant sources. Skins containing physical substances serve as a physical barrier which protects our bodies from pathogens. A healthy skin contains a variety of antibacterial substances such as defensin, cathelicidin and psoriasin. However deep and wide burns cause the skin to lose its original functions, so our skins are exposed to various danger factors. For the burn patients, human alloskin graft serves as a very important temporary biological wound dressing. It protects the wound before autograft procedure, forms revascularization and granulation tissues and protects the wound from an invasion of microbes. This study was conducted with the aim to analyze the antimicrobial effect of cryopreserved allograft (CPA) and glycerol-preserved allograft (GPA) which was a type of allograft widely used for burn patients, and measure the difference in comparison with the fresh skin before processing it. The most common contaminants found in burn patients such as S. aureus, P. aeruginosa, C. albicans and E. coli, were used for experiment. The antimicrobial effect against S. aureus and E. coli was observed in fresh skin and some CPA. In some clinical cases, infection is frequently observed in the wounds treated with allograft, indicating the allograft completely block every kind of microbes. To prevent the infection, it is required to use antibiotics and manage wounds thoroughly.Keywords
This publication has 23 references indexed in Scilit:
- Comparing the use of glycerol preserved and cryopreserved allogenic skin for the treatment of severe burns: differences in clinical outcomes and in vitro tissue viabilityCell and Tissue Banking, 2011
- Antibacterial properties of tualang honey and its effect in burn wound management: a comparative studyBMC Complementary and Alternative Medicine, 2010
- Biologic and synthetic skin substitutes: An overviewIndian Journal of Plastic Surgery, 2010
- The use of cultured epithelial autograft in the treatment of major burn wounds: Eleven years of clinical experienceBurns, 2006
- Burn Wound InfectionsClinical Microbiology Reviews, 2006
- Analysis of Skin-Graft Loss Due to InfectionAnnals of Plastic Surgery, 2005
- Expression of human β defensin 2 in thermal injuryClinical Dermatology and Surgery, 2004
- Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide AntibioticOnline Journal of Public Health Informatics, 2001
- In Vitro Penetration of Topical Antiseptics Through Eschar of Burn PatientsAnnals of Surgery, 1976
- Bacterial Invasion of the Stratum Corneum in ErythrasmaJournal of Investigative Dermatology, 1967