Survival outcomes of secondary cancers in patients with waldenström macroglobulinemia: An analysis of the SEER database
Open Access
- 11 May 2015
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 90 (8), 696-701
- https://doi.org/10.1002/ajh.24052
Abstract
We hypothesized that survival outcomes of WM patients who develop SM is distinct from the general population of individuals who develop those same malignancies. Using the SEER-18 data (2000–2011), we identified patients with cancers of the breast, prostate, lung, colorectum, bladder, melanoma, non-Hodgkin lymphoma (NHL), and acute leukemia, and compared their outcomes according to having antecedent WM or not. The outcome of interest was overall survival (OS), which was analyzed in proportional-hazard models adjusted for age, sex, race, and stage. We found that patients with WM who developed SM were older than population controls with those same cancers. In the multivariate analysis, WM cases with colorectal cancer (HR 1.97; P < 0.001), melanoma (HR 2.63; P < 0.001) and NHL (HR = 1.35; P = 0.02) had worse OS than controls with those respective cancers. WM patients with diffuse large B-cell lymphoma also had worse OS (HR = 1.86; P = 0.008). The utilization of surgery and radiation was similar between WM cases and controls, except lower rates of prostatectomy and melanoma surgery among WM patients. The survival of WM patients with colorectal cancer, melanoma, and NHL is worse than among general population controls, arguing in favor of age-appropriate cancer screening. Am. J. Hematol. 90:696–701, 2015.This publication has 25 references indexed in Scilit:
- Overall survival and competing risks of death in patients with Waldenström macroglobulinaemia: an analysis of the Surveillance, Epidemiology and End Results databaseBritish Journal of Haematology, 2014
- Survival trends in Waldenström macroglobulinemia: an analysis of the Surveillance, Epidemiology and End Results databaseBlood, 2014
- Epidemiology and survival outcomes of ocular and mucosal melanomas: A population‐based analysisInternational Journal of Cancer, 2013
- Overall and Cancer-Specific Survival of Patients With Breast, Colon, Kidney, and Lung Cancers With and Without Chronic Lymphocytic Leukemia: A SEER Population-Based StudyJournal of Clinical Oncology, 2013
- Chronic Lymphocytic Leukemia Is Associated With Decreased Survival of Patients With Malignant Melanoma and Merkel Cell Carcinoma in a SEER Population-Based StudyJournal of Clinical Oncology, 2012
- Second malignancies among Waldenstrom macroglobulinemia patients: small samples and sparse dataAnnals of Oncology, 2011
- Risk of second cancers in Waldenström macroglobulinemiaAnnals of Oncology, 2011
- Associated Malignancies in Patients with Waldenström's Macroglobulinemia and Their KinClinical Lymphoma Myeloma and Leukemia, 2011
- InterLymph hierarchical classification of lymphoid neoplasms for epidemiologic research based on the WHO classification (2008): update and future directionsBlood, 2010
- Liposomal vincristine for the treatment of human acute lymphoblastic leukaemia in severe combined immunodeficient (SCID) miceBritish Journal of Haematology, 1998