Prevalence of comorbidity in chronic HCV‑infection
- 11 April 2021
- journal article
- Published by Alfmed LLC in Medical alphabet
- No. 1,p. 66-70
- https://doi.org/10.33667/2078-5631-2021-1-66-70
Abstract
The effect of the comorbid background on the course of the infectious process in chronic HCV infection requires study due to the existence of a risk of progression of liver fibrosis even after the eradication of the virus against the background of concomitant diseases.Material and methods. The article analyzes the prevalence of various comorbid conditions in 700 patients with chronic HCV infection, who were observed in the hospital of the Botkin in St. Petersburg, an assessment of the mutual influence of the comorbid background and the progression of liver fibrosis in HCV infection was given. To determine the contribution of comorbidity to the course of HCV infection, the odds ratio (OR) parameters were calculated.Results. HCV-infected individuals have higher prevalence of comorbidity (63 %) and multimorbidity (50 %). In patients with severe fibrosis or cirrhosis, the presence of the comorbidity factor increased to 85 %. In the examined group of patients, diseases of the biliary tract and pancreas prevailed (30.0 %), occult Hepatitis B Infection was revealed in 19.0 %, in 15.4 % – cardiovascular diseases, in 13.7 % – diseases of the upper gastrointestinal tract. Diabetes mellitus was found in 4.6 % of patients, and obesity – in 5.9 %, kidney disease – 3.0 %. The remaining concomitant diseases occurred in less than 2.0 % of the observed patients. It has been established that diseases of the biliary tract and pancreas, gastrointestinal tract, diabetes mellitus, obesity, cardiovascular diseases are risk factors for the development of liver fibrosis in chronic HCV infection.Conclusions. The data obtained indicate the need for a more personalized approach to monitoring patients and the need to create integrated models of medical care for patients with chronic hepatitis C.Keywords
This publication has 22 references indexed in Scilit:
- Clinical features of the comorbid course of non-alcoholic fatty liver disease and gallstone diseaseTerapevticheskii arkhiv, 2020
- HCV-infected individuals have higher prevalence of comorbidity and multimorbidity: a retrospective cohort studyBMC Infectious Diseases, 2019
- HCV Extrahepatic ManifestationsJournal of Clinical and Translational Hepatology, 2019
- Elimination of hcv-infection: a history with continuationJournal Infectology, 2018
- Predictors of advanced fibrosis in non‐cirrhotic non‐alcoholic fatty liver disease in GermanyAlimentary Pharmacology & Therapeutics, 2018
- Hepatitis C virus infection and risk of gallstones: A meta-analysisJournal of Evidence-Based Medicine, 2017
- Role of occult hepatitis B virus infection in chronic hepatitis CWorld Journal of Gastroenterology, 2015
- Facts and fictions of HCV and comorbidities: Steatosis, diabetes mellitus, and cardiovascular diseasesJournal of Hepatology, 2014
- Hepatitis C virus infection is a risk factor for gallstone disease: a prospective hospital‐based study of patients with chronic viral C hepatitisJournal of Viral Hepatitis, 2009
- Hepatitis C virus may infect extrahepatic tissues in patients with hepatitis CWorld Journal of Gastroenterology, 2000