Wnt signalling in oral and maxillofacial diseases
- 13 October 2021
- journal article
- review article
- Published by Wiley in Cell Biology International
- Vol. 46 (1), 34-45
- https://doi.org/10.1002/cbin.11708
Abstract
Wnts include more than 19 types of secreted glycoproteins that are involved in a wide range of pathological processes in oral and maxillofacial diseases. The transmission of Wnt signalling from the extracellular matrix into the nucleus includes canonical pathways and non-canonical pathways, which play an important role in tooth development, alveolar bone regeneration and related diseases. In recent years, with the in-depth study of Wnt signalling in oral and maxillofacial-related diseases, many new conclusions and perspectives have been reached, and there are also some controversies. This article aims to summarize the roles of Wnt signalling in various oral diseases, including periodontitis, dental pulp disease, jaw disease, cleft palate, and abnormal tooth development, to provide researchers with a better and more comprehensive understanding of Wnts in oral and maxillofacial diseases.Keywords
Funding Information
- National Natural Science Foundation of China (82001020)
- China Postdoctoral Science Foundation (2019M663525)
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