Therapeutic actions of curcumin in bone disorders
- 2 March 2016
- journal article
- review article
- Published by Portico in BoneKEy Reports
- Vol. 5, 793
- https://doi.org/10.1038/bonekey.2016.20
Abstract
Curcumin is the active component of turmeric extract derived from the Curcuma longa plant. In the last decade, curcumin has raised a considerable interest in medicine owing to its negligible toxicity and multiple therapeutic actions including anti-cancer, anti-inflammatory and anti-microbial activities. Among the various molecular targets of curcumin, some are involved in bone remodeling, which strongly suggests that curcumin can affect the skeletal system. The review sheds light on the current and potential applications of curcumin to treat bone disorders characterized by an excessive resorption activity. Within the scope of this review, the novel formulations of curcumin to overcome its physico-chemical and pharmacokinetic constraints are also discussed.Keywords
This publication has 69 references indexed in Scilit:
- Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblastsInternational Journal of Nanomedicine, 2014
- Effects of Curcumin on the Proliferation and Mineralization of Human Osteoblast-Like Cells: Implications of Nitric OxideInternational Journal of Molecular Sciences, 2012
- Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applicationsInternational Journal of Nanomedicine, 2012
- Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung CancerInternational Journal of Molecular Sciences, 2012
- Curcumin nanoformulations: a future nanomedicine for cancerDrug Discovery Today, 2012
- Breast cancer metastasis to the bone: mechanisms of bone lossBreast Cancer Research, 2010
- Notch signaling contributes to the pathogenesis of human osteosarcomasHuman Molecular Genetics, 2009
- CURCUMIN: THE INDIAN SOLID GOLDPublished by Springer Science and Business Media LLC ,2007
- Mechanisms of Bone MetastasisThe New England Journal of Medicine, 2004
- Therapeutic potential of curcumin in prostate cancer—IV: Interference with the osteomimetic properties of hormone refractory C4‐2B prostate cancer cellsThe Prostate, 2003