Tracking regional brain growth up to age 13 in children born term and very preterm
Open Access
- 4 February 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 11 (1), 1-11
- https://doi.org/10.1038/s41467-020-14334-9
Abstract
Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto–frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth.Keywords
This publication has 64 references indexed in Scilit:
- Contribution of Brain Size to IQ and Educational Underperformance in Extremely Preterm AdolescentsPLOS ONE, 2013
- FreeSurferNeuroImage, 2012
- Global and Regional Differences in Brain Anatomy of Young Children Born Small for Gestational AgePLOS ONE, 2011
- A reproducible evaluation of ANTs similarity metric performance in brain image registrationNeuroImage, 2011
- Structural MRI of Pediatric Brain Development: What Have We Learned and Where Are We Going?Neuron, 2010
- Socioeconomic status and the developing brainTrends in Cognitive Sciences, 2009
- Longitudinal Brain Volume Changes in Preterm and Term Control Subjects During Late Childhood and AdolescencePEDIATRICS, 2009
- Brain injury in premature infants: a complex amalgam of destructive and developmental disturbancesThe Lancet Neurology, 2009
- A Structural MRI Study of Human Brain Development from Birth to 2 YearsJournal of Neuroscience, 2008
- Sexual dimorphism of brain developmental trajectories during childhood and adolescenceNeuroImage, 2007