The role of miRNAs in COVID-19 disease
Open Access
- 1 April 2021
- journal article
- review article
- Published by Future Medicine Ltd in Future Virology
- Vol. 16 (4), 301-306
- https://doi.org/10.2217/fvl-2020-0389
Abstract
Nowadays, the SARS Coronavirus 2 (SARS-CoV-2) infection is recognized as the primary cause of mortality in humans. SARS-CoV-2 is transmitted through human-to-human contact and is asymptomatic in most patients. In addition to approved vaccines against SARS-CoV-2 infection, miRNAs may also be promising options against this new virus. miRNAs are small and noncoding RNAs 18–25 nucleotides in length that target the mRNAs to degrade them or obstruct their translation miRNAs act as an observer in cells. This study reviewed the literature on the potential role of cellular miRNAs in the SARS-CoV-2-host interplay as a therapeutic option in COVID-19 patients.Keywords
This publication has 27 references indexed in Scilit:
- Rapid and label‐free electrochemical DNA biosensor based on a facile one‐step electrochemical synthesis of rGO–PPy–(L‐Cys)–AuNPs nanocomposite for the HTLV‐1 oligonucleotide detectionBiotechnology and Applied Biochemistry, 2020
- What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?Infection, Genetics and Evolution, 2020
- Computational analysis of microRNA-mediated interactions in SARS-CoV-2 infectionPeerJ, 2020
- The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for ComorbiditiesViruses, 2020
- Comparison of the COVID-2019 (SARS-CoV-2) pathogenesis with SARS-CoV and MERS-CoV infectionsFuture Virology, 2020
- Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor bindingThe Lancet, 2020
- Re-epithelialization and immune cell behaviour in an ex vivo human skin modelScientific Reports, 2020
- COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/ProfileAging and disease, 2020
- The Role of microRNAs in the Viral InfectionsCurrent Pharmaceutical Design, 2019
- Circulating inflamma-miRs in aging and age-related diseasesFrontiers in Genetics, 2013