The antidepressants effects on microbiota: unobvious possibilities Research article
Open Access
- 29 December 2021
- journal article
- Published by V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology in V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY
- Vol. 57 (4), 8-14
- https://doi.org/10.31363/2313-7053-2021-57-4-8-14
Abstract
Despite the emergence of new antidepressants with different mechanisms of action, a large number of problems in antidepressant therapy remain. Considering the known antimicrobial activity of antidepressants, the role of the microbiota in the thymoanaleptic activity of these drugs is of high interest. In recent years, important data have been obtained on the role of the gut microbiota in the regulation of behavior and the pathophysiology of a number of mental disorders, including depression. Of particular interest is the assessment of the normal intestinal microbiota role in the course of the therapeutic process. The emerging bi-directional interactions between drugs and microorganisms may be critical for personalized drug selection and future drug development. However, at the present time, this problem remains poorly understood. The proposed manuscript articulates the main directions that are of clinical importance and can become an object for further study in this area.The research results indicate that the effect of antidepressants on the microbiota is a promising area, the study of which could provide many important findings for clinical practice. This type of therapeutic manipulation can provide an opportunity for intervention in order to potentiate the activity of antidepressants or to minimize side effects. The problem with this method of intervention is enormous complexity, when manipulations can have both positive and negative effects simultaneously, depending on different strains of microorganisms influencing different therapeutic effects. More research is needed to understand what changes occur in the microbiome with acute and chronic administration of specific antidepressants. Perhaps this will contribute to the development of microbiomodulatory tactics for individualized interventions.Keywords
This publication has 45 references indexed in Scilit:
- Depression, antidepressant medications, and risk of Clostridium difficileinfectionBMC Medicine, 2013
- Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-associated microbesGut Pathogens, 2012
- Association of depressive disorders, depression characteristics and antidepressant medication with inflammationTranslational Psychiatry, 2012
- Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerveProceedings of the National Academy of Sciences of the United States of America, 2011
- A man who wanted to commit suicide by hanging himself: an adverse effect of ciprofloxacinGeneral Hospital Psychiatry, 2011
- Serum levels of brain-derived neurotrophic factor in major depressive disorder: state–trait issues, clinical features and pharmacological treatmentMolecular Psychiatry, 2010
- Indole as an intercellular signal in microbial communitiesFEMS Microbiology Reviews, 2010
- Treatment resistance in unipolar depression: Is it an iatrogenic phenomenon caused by antidepressant treatment of patients with a bipolar diathesis?Medical Hypotheses, 2006
- Antimicrobial activity of psychotropic drugs: Selective serotonin reuptake inhibitorsInternational Journal of Antimicrobial Agents, 2000
- Antidepressant tachyphylaxisMedical Hypotheses, 1984