Polyoxygenated Terpenoids and Polyketides from the Roots of Flueggea virosa and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation
Open Access
- 5 December 2022
- Vol. 27 (23), 8548
- https://doi.org/10.3390/molecules27238548
Abstract
Six new polyoxygenated terpenoids, podovirosanes A–F (1–6), and two known polyketides (7 and 8) were isolated from the roots of F. virosa. Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as computational calculations, including TDDFT calculation of ECD spectra and GIAO NMR calculations combined with DP4+ probability analysis. Compounds 2, 3, 5, and 8 were found to reduce the phosphorylation levels of NF-κB p65 in SARS-CoV-2 pseudovirus-stimulated PMA-differentiated THP-1 cells.Funding Information
- Ministry of Science and Technology of Taiwan (MOST101-2113-M-039-003, MOST106-2320-B-039-021)
- China Medical University (CMU111-TC-04, CMU109-S-49)
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