The effect of zolpidem on targeted memory reactivation during sleep
Open Access
- 16 August 2021
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 28 (9), 307-318
- https://doi.org/10.1101/lm.052787.120
Abstract
According to the active system consolidation theory, memory consolidation during sleep relies on the reactivation of newly encoded memory representations. This reactivation is orchestrated by the interplay of sleep slow oscillations, spindles, and theta, which are in turn modulated by certain neurotransmitters like GABA to enable long-lasting plastic changes in the memory store. Here we asked whether the GABAergic system and associated changes in sleep oscillations are functionally related to memory reactivation during sleep. We administered the GABAA agonist zolpidem (10 mg) in a double-blind placebo-controlled study. To specifically focus on the effects on memory reactivation during sleep, we experimentally induced such reactivations by targeted memory reactivation (TMR) with learning-associated reminder cues presented during post-learning slow-wave sleep (SWS). Zolpidem significantly enhanced memory performance with TMR during sleep compared with placebo. Zolpidem also increased the coupling of fast spindles and theta to slow oscillations, although overall the power of slow spindles and theta was reduced compared with placebo. In an uncorrected exploratory analysis, memory performance was associated with slow spindle responses to TMR in the zolpidem condition, whereas it was associated with fast spindle responses in placebo. These findings provide tentative first evidence that GABAergic activity may be functionally implicated in memory reactivation processes during sleep, possibly via its effects on slow oscillations, spindles and theta as well as their interplay.Keywords
Funding Information
- DFG) and the Consejo Nacional de Investigaciones Cientificas y Técnicas/Ministerio de Ciencia, Tecnologia e Innovación de la Nación (DI 1866/2-1, 4427)
- Deutscher Akademischer Austauschdienst
This publication has 68 references indexed in Scilit:
- Pharmacologically Increasing Sleep Spindles Enhances Recognition for Negative and High-arousal MemoriesJournal of Cognitive Neuroscience, 2013
- Slow Wave Sleep Induced by GABA Agonist Tiagabine Fails to Benefit Memory ConsolidationSleep, 2013
- An opportunistic theory of cellular and systems consolidationTrends in Neurosciences, 2011
- Fast and Slow Spindles during the Sleep Slow Oscillation: Disparate Coalescence and Engagement in Memory ProcessingSleep, 2011
- Strengthening Individual Memories by Reactivating Them During SleepScience, 2009
- The Sleeping Brain's Influence on Verbal Memory: Boosting Resistance to InterferencePLOS ONE, 2009
- The contribution of sleep to hippocampus-dependent memory consolidationTrends in Cognitive Sciences, 2007
- The sleep–wake cycle and sleeping pillsPhysiology & Behavior, 2007
- High Gamma Power Is Phase-Locked to Theta Oscillations in Human NeocortexScience, 2006
- Reactivation of Hippocampal Ensemble Memories During SleepScience, 1994