Antidiabetic and Antioxidant Effects of Methanolic Extracts of Leaf and Seed of Tetracarpidium conophorum on Alloxan-Induced Diabetic Wistar Rats
Open Access
- 1 January 2017
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Journal of Biomedical Science and Engineering
- Vol. 10 (08), 402-420
- https://doi.org/10.4236/jbise.2017.108031
Abstract
Methanolic extracts of Tetracarpidium conophorum (TCME) leaf, seed or leaf + seed extract demonstrated high capacity for reversing hyperglycemia and oxidative stress comparable with the standard anti-diabetic drug, metformin, in alloxan-induced diabetic rats. The leaf + seed extracts showed the best activity among the extracts and also ameliorated oxidative stress-induced damage of pancreas and liver tissue to normal state.Keywords
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