Education is a process through which mankind transmit experience, new findings and value accumulate over time with the aim of individuals and societies, to make all around participation in the development process. Sufficient healthy intake of food is essential to brain function. Moreover, maximizing brain function is a prime factor in seizing appropriate cognitive capability for example, ability to focus, comprehension, evaluation, and application in learning. Therefore, food is advisable take account for quality and stuffiness of food to protect our students from different infection and declining on their academic performance. The study was trying to assess the impact of Debre Berhan university cafeteria food related problems on the academic achievement of students. The general objective of the study is to analyze statistically the impact of food related problems on academic achievement of students. The study used well organized questionnaire and the source of data is primary data which will done by direct contact of respondents and secondary data which will be obtained from the registrar of Debre Berhan university. The collected data is analyzed by using descriptive and inferential statistics. The sample size determination is made by using statistical formula. Descriptive statistics and multiple linear regression analysis is applied to examine the relationship between the dependent variable academic achievement and food related problem independent variables. Multiple linear regression model is a mathematical equation that provides prediction of the value of dependent variable based on known value of independent variables. The analysis of multiple linear regression revealed that the academic achievement of students was mostly affected by adequacy of food supply, quality of cafeteria sanitation, health related problem, food sanitation and personal hygiene of cafeteria workers, time of cafeteria and those factors affect the academic achievement of students.