Mercury and Mercury-Containing Preparations: History of Use, Clinical Applications, Pharmacology, Toxicology, and Pharmacokinetics in Traditional Chinese Medicine
Open Access
- 2 March 2022
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 13, 807807
- https://doi.org/10.3389/fphar.2022.807807
Abstract
Historically, mercury and mercury-containing preparations have been widely used in traditional Chinese medicine and applied in many clinical practices mainly in the form of mercury sulfides. The clinical application, toxicity manifestations, and symptoms of these preparations largely depend on the route of administration and the dosage form. Commonly used mercury-containing medicinal materials and preparations in traditional Chinese medicine include Cinnabar, an excellent medicine for tranquilizing the nerves; Hongsheng Dan and Baijiang Dan, which have antibacterial, anti-inflammatory, promotion of tissue repair and regeneration and other pharmacological effects. Tibetan medicine commonly uses Zaotai and Qishiwei Zhenzhu pills, which have pharmacological effects such as sedation, anti-inflammatory, anti-convulsant, and improvement of cerebral apoplexy. Menggen Wusu Shibawei pills, commonly used in Mongolian traditional medicine, have the muscle growth and astringent effects. In India and Europe, mercury is often used for treating syphilis. This article summarizes the history, clinical application, pharmacology, toxicology, and pharmacokinetics of mercury and mercury-containing preparations in traditional medicines. In terms of clinical application, it provides suggestions for the rational use and safety of mercury-containing drugs in clinical practices and in public health issues. It will further provide a reference for formulation strategies related to mercury risk assessment and management.Funding Information
- National Social Science Fund of China (19BMZ101)
- China Postdoctoral Science Foundation (2012M511916)
This publication has 79 references indexed in Scilit:
- Effects of Zhuhong ointment on MMPs activities and production by HSFChina Journal of Chinese Materia Medica, 2013
- Mercury ToxicityJournal of Biomedicine and Biotechnology, 2012
- Methylmercury: A potential environmental risk factor contributing to epileptogenesisNeuroToxicology, 2012
- Mercury Toxicity and Treatment: A Review of the LiteratureJournal of Environmental and Public Health, 2011
- Cytokine gene polymorphisms and graft-versus-host disease in children after matched sibling hematopoietic stem cell transplantation: a single-center experienceCellular & Molecular Immunology, 2011
- Realgar is active ingredient of Angong Niuhuang pill in protection against LPS-induced neuroinflammationChina Journal of Chinese Materia Medica, 2010
- Preparation of silver nanoparticles on cellulose nanocrystals and the application in electrochemical detection of DNA hybridizationCellulose, 2010
- Effect of Al Doping on Properties of SiC FilmsChinese Physics Letters, 2008
- Selective Effect of Mercury on Th2-Type Cytokine Production in HumansImmunopharmacology and Immunotoxicology, 2007
- The Chemical Form of Mercury in FishScience, 2003