The prevalence of obesity has increased signifi cantly and it has become a public health problem globally. Many strategies were done to overcome obesity. One of them is dietary approach. The popular and widely used weight loss diet is the ketogenic diet. This literature review aimed to discuss the mechanism of ketogenic diet in weight lost as well as its long and short term eff ects on health. Ketogenic diet is a very low-carbohydrate and high-fat diet. This diet restricts the carbohydrate intake up to 50 gram per day. The diet eff ective for losing weight in short term (