Retinal Postphotoreceptor Layers and Macular Electroretinogram in Retinitis Pigmentosa
Open Access
- 3 April 2020
- journal article
- Published by PE Polunina Elizareta Gennadievna in Ophthalmology in Russia
- Vol. 17 (1), 81-87
- https://doi.org/10.18008/1816-5095-2020-1-81-87
Abstract
Purpose: to assess the inner retinal layer’s changes of the central retina in comparison with bioelectrical activity of macula assessed by MERG and with thickness of photoreceptor retinal layers in patients with retinitis pigmentosa.Patients and methods: 10 patients (20 phakic eyes) with RP were examined. Mean age was 27.0 ± 18.5 years. Mean best corrected visual acuity was 0.38 ± 0.22. The fundus photography electrophysiological studies were performed besides standard ophthalmological examination. Maximal electroretinogram (ERG) or cone-rod response, ERG to 30 Hz flicker and macular ERG were registered with electroretinograph MBN (Russia). Images were acquired using the protocol of scanning Macula radial (12 lines 9 mm long, each radial image is the average out of 50 scans) with settings ultrafine with automatic segmentation of the retina and calculation thickness. Retinal segmentation with the following calculation of different retinal layers was performed on SD-OCT RS-3000 Advance (Nidek, Japan) with obtainment of the map with 6 mm in diameter in accordance with the Early Treatment Diabetic Retinopathy Study (ETDRS).Results. We revealed increased thickness of retinal nerve fiber layer (RNFL), decrease of thickness of ganglion cell layer (GCL) (p < 0,05) and normal (p > 0,05) inner nuclear layer (INL) thickness. These structural changes are associated with the decrease of bioelectric macula’s activity measured by MERG (decrease of α- and β-wave amplitude) and decrease the thickness of photoreceptor layers in all zones according to EDTRS.Conclusion. Increase of thickness RNFL, decrease of GCL’s thickness and normal INL in patients with RP is associated with decrease of thickness of photoreceptor layers in EDTRS zones and decrease of amplitude of MERG.Keywords
This publication has 20 references indexed in Scilit:
- Electroretinography and OCT angiography of the retina and optic nerve in retinitis pigmentosaRussian Ophthalmological Journal, 2017
- Retinal ProsthesisIEEE Transactions on Biomedical Engineering, 2014
- Repair of the degenerate retina by photoreceptor transplantationProceedings of the National Academy of Sciences of the United States of America, 2012
- Treatment Possibilities for Retinitis PigmentosaThe New England Journal of Medicine, 2010
- Retinal Nerve Fiber Layer Defects in RP PatientsInvestigative Ophthalmology & Visual Science, 2007
- Retinitis pigmentosaThe Lancet, 2006
- Yearly rates of rod and cone functional loss in retinitis pigmentosa and cone-rod dystrophyOphthalmology, 1999
- Preservation of the Inner Retina in Retinitis PigmentosaAmerican Journal of Ophthalmology, 1997
- Morphometric Analysis of Macular Photoreceptors and Ganglion Cells in Retinas With Retinitis PigmentosaAmerican Journal of Ophthalmology, 1992
- Natural Course of Retinitis Pigmentosa Over a Three-Year IntervalAmerican Journal of Ophthalmology, 1985